Welcome to the Harwani Lab
My group's research focuses on the interaction between the nervous system and the immune system/inflammation in hypertension. We are investigating the role of the “neuro-immune axis” in cardiovascular disease and specifically hypertension. Moreover, we have the goal of translating our “bench” discoveries to the “bedside".
Macrophages under pressure: the role of macrophage polarization in hypertension. Harwani SC. Translational Research. 2017 Nov 7. doi.org/10.1016/j.trsl.2017.10.011. [Epub ahead of print]
Nicotine Mediates CD161a+ Renal Macrophage Infiltration and Premature Hypertension in the Spontaneously Hypertensive Rat. Harwani SC, Ratcliff J, Sutterwala FS, Ballas ZK, Meyerholz DK, Chapleau MW, Abboud FM. Circ Res. 2016 Oct 28;119(10):1101-1115. Epub 2016 Sep 22.
The immune system and hypertension. Singh MV, Chapleau MW, Harwani SC, Abboud FM. Immunol Res. 2014 Aug;59(1-3):243-53. doi: 10.1007/s12026-014-8548-6. Review.
Neurohormonal modulation of the innate immune system is proinflammatory in the prehypertensive spontaneously hypertensive rat, a genetic model of essential hypertension. Harwani SC, Chapleau MW, Legge KL, Ballas ZK, Abboud FM. Circ Res. 2012 Oct 12;111(9):1190-7. doi: 10.1161/CIRCRESAHA.112.277475. Epub 2012 Aug 17.
Autonomic neural regulation of the immune system: implications for hypertension and cardiovascular disease. Abboud FM, Harwani SC, Chapleau MW. Hypertension. 2012 Apr;59(4):755-62. doi: 10.1161/HYPERTENSIONAHA.111.186833. Epub 2012 Feb 13. Review.